高旭

副研究员、助理教授、博士生导师
xu.gao@hsc.pku.edu.cn
北京市海淀区学院路38号
北京大学

个人简介

151amjs澳金沙门劳动卫生与环境卫生学系副研究员、博士生导师。主要从事精准环境健康与衰老流行病学研究。目前已在Nature Aging、Nature Cardiovascular Research、Nature Communications、American Journal of Respiratory and Critical Care Medicine、Environmental Health Perspectives、Environmental Science & Technology、International Journal of Epidemiology和 European Journal of Epidemiology等国际权威期刊发表SCI论文60余篇，承担国家自然科学基金、国家重点研发计划等。受聘国际环境流行病学会ISEE执行委员、中华预防医学会环境卫生分会委员、中国老年医学学会流行病学与疾病预防分会委员等。担任Current Environmental Health Reports编委，以及The Innovation和环境卫生学杂志青年编委。

教育及工作经历

2006 – 2011 学士（预防医学）复旦大学

2011 – 2014 硕士（基础医学）复旦大学

2014 – 2018 博士（流行病学，最高荣誉summa cum laude）海德堡大学（德国）

2018 – 2020 博士后研究员（环境健康学）哥伦比亚大学（美国）

主要研究方向

衰老；精准环境健康；脑健康；老年健康；流行病学

代表性科研项目

1. 国家自然科学基金（82304098）：基于SLC25A51基因甲基化动态调控研究黑碳损伤老年人认知功能的作用机制。2024.1 – 2026.12 主持

2. 广西环境暴露组学与全生命周期健康重点实验室开放课题（2023-GKLEH-03）：老年人环境重金属暴露与生物学年龄的长寿队列研究。2023.10-2025.09 主持

3. 中国疾病预防控制中心环境与人群健康重点实验室开放基金（2022-CKL-03）：镉与砷慢性暴露对老年人虚弱状态的影响及 DNA 甲基化机制研究。 2022.01-2023.12 主持

4. 国家重点研发计划（2022YFC3702704）：中国居民对大气污染响应的全生命过程健康效应谱研究。2022.10-2026.03 项目骨干

5. 美国NIH R01 基金（R01ES025225）: Circulating microRNAs in Extracellular Vesicles, Air Particulate Pollution, and Lung Function in an Aging Cohort. 2018 – 2020 参与

6. 美国NIH R01 基金（R01ES027747）: Air Particulate, Metals, and Cognitive Performance in an Aging Cohort – Roles of Circulating Extracellular Vesicles and Non-coding RNAs. 2018 – 2020 参与

7. 意大利嘉利堡基金会Fondazione Cariplo老龄化疾病研究专项（2017-0653）：The Trithorax and Polycomb group proteins UTX and EzH2 in the Frailty Syndrome. 2017-2020 参与

10篇代表性论文

1. Jiang M, Tian S, Liu S, Wang Y, Guo X, Huang T, Lin X, Belsky D, Baccarelli AA, Gao X*. Accelerated biological aging elevates the risk of cardiometabolic multimorbidity and mortality. Nature Cardiovascular Research, 2024. doi: 10.1038/s44161-024-00438-8. (专题报道)

2. Gao X*, Tong G, Jiang M, Huang N, Zheng Y, Belsky D*, Huang T. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nature Communications, 2023, doi: 10.1038/s41467-023-38013-7. (IF = 16.6)

3. Gao X*, Jiang M, Huang N, Guo X, Huang T. Long-Term Air Pollution, Genetic Susceptibility, and the Risk of Depression and Anxiety: A Prospective Study in the UK Biobank Cohort. Environmental Health Perspectives, 2023, doi: 10.1289/EHP10391. (IF = 10.4)

4. Gao X#, Huang J#, Cardenas A, Zhao Y, Sun Y, Wang J, Xue L, Baccarelli AA, Guo X, Zhang L, Wu S. Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study. Environmental Science & Technology, 2022, doi: 10.1021/acs.est.2c05534. (IF = 11.4)

5. Gao X*, Coull B, Lin X, Vokonas P, Spiro A III, Hou L, Schwartz J, Baccarelli AA. Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study. Nature Aging. 2021; 1(5):430-437. doi:10.1038/s43587-021-00060-4. （IF = 16.6; 封面文章）

6. Gao X*, Coull B, Lin X, Vokonas P, Sparrow D, Hou L, DeMeo D, Litonjua A, Schwartz J, Baccarelli AA. Association of Neutrophil to Lymphocyte Ratio with Reduced Pulmonary Function in a 30-Year Longitudinal Study of US Veterans. JAMA Network Open. 2020; 3:e2010350. (IF = 13.8)

7. Gao X*, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. Nonsteroidal anti-inflammatory drugs modify the effect of short-term air pollution on lung function. American Journal of Respiratory and Critical Care Medicine. 2020; 201(3):374-8. (IF = 24.7)

8. Gao X*, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environment International. 2019; 126, 395-405. doi: 10.1016/j.envint.2019.02.053. (IF = 11.8)

9. Gao X, Gào X, Zhang Y, Holleczek B, Schöttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. European Journal of Epidemiology. 2019; 451-462. (IF = 13.6)

10. Gao X*, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli AA. Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. International Journal of Epidemiology. 2019; 48, 1958-1971. (IF = 7.7)